Dr. Chunqi Qian is applying for the K99/R00 career transition award in preparation for his immediate career goal to become an independent faculty member in an academic institution. Dr. Qian's long term career goal is to develop advanced detection technologies for the next generation MRI diagnosis with better sensitivity and accuracy. To achieve this goal, Dr. Qian has been continuously working in the research field of magnetic resonance for many years. His PhD thesis work was highlighted by the prestigious professional journal, the Journal of Magnetic Resonance, for his novel implementation of the wireless coupling technique in the construction of a variable angle MR detector. During his postdoctoral research at the National High Magnetic Field Laboratory, Dr. Qian successfully constructed a broad range tunable detector with good homogeneity and efficiency for the world's highest field MRI at 21.1 Tesla. This important progress has thus enabled the practical exploitation of high field magnet for biomedical imaging. This work has also been honored by the Young Investigator Award during the International Conference in Magnetic Resonance Microscopy. As a research fellow at NIH, Dr. Qian has for the first time developed a very promising technology that can greatly enhance the MRI detection sensitivity of internal organs, based on the innovative design concept of wireless amplified detection. This new technology has already been applied to obtain high resolution images of rodent kidney in vivo, enabling the detection of individual glomeruli and renal tubules. To further improve the imaging resolution, Dr. Qian will reduce the motional artifact by dynamically tracking the object motion with implanted detector itself, as is mentioned in Aim 1. To maximize the image contrast, Dr. Qian will use different contrast agents to visualize different components of nephron and correlate these high resolution images with histological studies, as is mentioned in Aim 2. These two specific aims will be accomplished under the mentorship of Dr. Alan Koretsky, during which time Dr. Qian will receive complete support from the NINDS. After Dr. Qian obtains an independent faculty position, he will continue the development of the wireless amplifier technology and exploit its biomedical applications. As is summarized in Aim 3, Dr. Qian will fabricate miniaturized wireless amplified detectors with microfabrication techniques. As is summarized in Aim 4, Dr. Qian will construct arrayed wireless detectors to get a bigger field-of-view, where each detector can be individually manipulated by a specific pumping signal. It is anticipated that further development of the wireless amplifier technology will lead to such applications as the chronic monitoring of engineered tissues and the in situ chemical sensing inside the digestive track.

Public Health Relevance

This project seeks to develop a generally applicable technology that can greatly enhance the MRI detection sensitivity of internal organs by in situ amplification of the weak MR signals with a wireless power source. This new MRI detection technology will be very useful for disease diagnosis with better sensitivity and accuracy.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Transition Award (R00)
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Special Emphasis Panel (NSS)
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Liu, Guoying
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Michigan State University
Schools of Osteopathic Medicine
East Lansing
United States
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Fan, Baolei; Li, Tingting; Song, Xiaofang et al. (2018) A rapid, accurate and sensitive method for determination of monosaccharides in different varieties of Osmanthus fragrans Lour by pre-column derivatization with HPLC-MS/MS. Int J Biol Macromol :
Enomoto, Ayano; Qian, Chunqi; Devasahayam, Nallathamby et al. (2018) Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications. Magn Reson Med 80:2288-2298
Hossaini Nasr, Seyedmehdi; Tonson, Anne; El-Dakdouki, Mohammad H et al. (2018) Effects of Nanoprobe Morphology on Cellular Binding and Inflammatory Responses: Hyaluronan-Conjugated Magnetic Nanoworms for Magnetic Resonance Imaging of Atherosclerotic Plaques. ACS Appl Mater Interfaces 10:11495-11507
Fan, Baolei; You, Jinmao; Suo, Yourui et al. (2018) A novel and sensitive method for determining vitamin B3 and B7 by pre-column derivatization and high-performance liquid chromatography method with fluorescence detection. PLoS One 13:e0198102
Gjesteby, Lars; Cong, Wenxiang; Yang, Qingsong et al. (2018) Simultaneous Emission-Transmission Tomography in an MRI Hardware Framework. IEEE Trans Radiat Plasma Med Sci 2:326-336
Ma, Shuangtao; Qian, Chunqi; Wang, Donna (2018) Tracking renal injury using multi-parametric MRI. Am J Physiol Renal Physiol :
Xu, Shengqiang; Nasr, Seyedmehdi Hossaini; Chen, Daoyang et al. (2018) MiRNA extraction from cell-free biofluid using protein corona formed around carboxyl magnetic nanoparticles. ACS Biomater Sci Eng 4:654-662
Zeng, Xianchun; Xu, Shengqiang; Cao, Changyong et al. (2018) Wireless amplified NMR detector for improved visibility of image contrast in heterogeneous lesions. NMR Biomed 31:e3963
Zeng, Xianchun; Barbic, Mladen; Chen, Liangliang et al. (2017) Sensitive enhancement of vessel wall imaging with an endoesophageal Wireless Amplified NMR Detector (WAND). Magn Reson Med 78:2048-2054
Zeng, Xianchun; Chen, Liangliang; Wang, Chuan et al. (2017) Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls. Sci Rep 7:4228

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