The recently discovferecl rhesus monkey protein;TRIM5

Public Health Relevance

The main goal of this proposal is to gain understanding on how the host factor TRIMSalpha potently blocks HIV-1 infection. In contrast to the rhesus monkey TRIMSalpha, the human homologue poorly restricts HIV-1. Understanding the anti-HIV-1 activity of TRIMSalpha rhesus will generate new therapeutic opportunities to improve the anti-HIV-1 activity of human TRIMSalpha.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Transition Award (R00)
Project #
4R00MH086162-02
Application #
8015748
Study Section
Special Emphasis Panel (NSS)
Program Officer
Joseph, Jeymohan
Project Start
2010-03-01
Project End
2012-02-28
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
2
Fiscal Year
2010
Total Cost
$249,000
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
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Yudina, Zinaida; Roa, Amanda; Johnson, Rory et al. (2015) RING Dimerization Links Higher-Order Assembly of TRIM5? to Synthesis of K63-Linked Polyubiquitin. Cell Rep 12:788-97
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Valle-Casuso, Jose Carlos; Di Nunzio, Francesca; Yang, Yang et al. (2012) TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core. J Virol 86:5931-6
Diaz-Griffero, Felipe; Gallo, Daniel E; Hope, Thomas J et al. (2011) Trafficking of some old world primate TRIM5? proteins through the nucleus. Retrovirology 8:38

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