The recently discovferecl rhesus monkey protein;TRIM5 The main goal of this proposal is to gain understanding on how the host factor TRIMSalpha potently blocks HIV-1 infection. In contrast to the rhesus monkey TRIMSalpha, the human homologue poorly restricts HIV-1. Understanding the anti-HIV-1 activity of TRIMSalpha rhesus will generate new therapeutic opportunities to improve the anti-HIV-1 activity of human TRIMSalpha.Public Health Relevance
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