Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA008213-01A1
Application #
3112222
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1990-07-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Ronis, M J; Huang, J; Longo, V et al. (1998) Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions. Biochem Pharmacol 55:123-9
Hu, Y; Mishin, V; Johansson, I et al. (1994) Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. J Pharmacol Exp Ther 269:1286-91
Badger, T M; Ronis, M J; Ingelman-Sundberg, M et al. (1993) Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusions in rats. Alcohol 10:453-7
Badger, T M; Huang, J; Ronis, M et al. (1993) Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem Biophys Res Commun 190:780-5
Badger, T M; Crouch, J; Irby, D et al. (1993) Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: continuous vs. cyclic ethanol and nutrient infusions. J Pharmacol Exp Ther 264:938-43
Ronis, M J; Huang, J; Crouch, J et al. (1993) Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J Pharmacol Exp Ther 264:944-50
Badger, T M; Ronis, M J; Lumpkin, C K et al. (1993) Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J Pharmacol Exp Ther 264:438-47
Ronis, M J; Lumpkin, C K; Thomas, P E et al. (1992) The microsomal monooxygenase system of regenerating liver. An examination of the role of estradiol in the demasculinization of drug metabolism produced by 2/3 partial hepatectomy. Biochem Pharmacol 43:567-73
Ronis, M J; Lumpkin, C K; Ingelman-Sundberg, M et al. (1991) Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat. Alcohol Clin Exp Res 15:693-9