This is a request for continued funding for unique study of adoptive and non-adoptive families, the Sibling Interaction and Behavior Study (SIBS). The major aim of SIBS is to investigate the origins of adolescent alcohol use and abuse and associated behavioral pathology within a developmental biopsychosocial framework. In the initial period of funding, we systematically ascertained and assessed 409 adoptive and 208 non-adoptive families, each consisting of a pair of adolescent siblings and their rearing parents. Families completed an extensive 5-hour, in-person assessment that included measurement of substance use and abuse, mental health, family and social environment, and individual-level markers of risk. In this continuation proposal, we seek to complete analysis of the intake SIBS dataset and explore the interplay of genetic and environmental influences on adolescent development. In completing the analysis of the intake SIBS dataset, we will test the following hypotheses: 1) shared environmental influences exert a consistent effect on adolescent disinhibitory psychopathology, including adolescent alcohol use, and 2) siblings, rather than parents, are the major source of shared environmental influence on adolescent disinhibitory behavior. To investigate gene-environment interplay, SIBS participants will be genotyped on 8-12 candidate genes selected as being relevant to vulnerability to disinhibitory psychopathology. Our sample of adopted adolescents includes a sizable number of East Asians, who will also be genotyped on the ALDH2 polymorphism. Analysis of the ALDH2 data will focus not only on whether it is protective against alcohol consumption in East Asians reared in non-East Asian homes, but also on the factors that account for heavy alcohol consumption among East Asian adolescents who inherit ALDH2 deficiency. In the analysis of the ALDH2 data, we will also make use of the principles of Mendelian randomization to test the hypothesis that reducing adolescent drinking also results in reductions in other problem behaviors.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-HOP-T (02))
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Bryant, Kendall
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University of Minnesota Twin Cities
Schools of Arts and Sciences
United States
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Park, Jun Young; Wu, Chong; Basu, Saonli et al. (2018) Adaptive SNP-Set Association Testing in Generalized Linear Mixed Models with Application to Family Studies. Behav Genet 48:55-66
Lee, James J; McGue, Matt; Iacono, William G et al. (2018) The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies. Genet Epidemiol 42:783-795
Samek, Diana R; Goodman, Rebecca J; Riley, Lucy et al. (2018) The Developmental Unfolding of Sibling Influences on Alcohol Use over Time. J Youth Adolesc 47:349-368
Sniekers, Suzanne; Stringer, Sven; Watanabe, Kyoko et al. (2017) Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat Genet 49:1107-1112
McGue, Matt; Rustichini, Aldo; Iacono, William G (2017) Cognitive, Noncognitive, and Family Background Contributions to College Attainment: A Behavioral Genetic Perspective. J Pers 85:65-78
Lam, Max; Trampush, Joey W; Yu, Jin et al. (2017) Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep 21:2597-2613
Weiss, Alexander; Baselmans, Bart M L; Hofer, Edith et al. (2016) Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet 19:407-17
Spain, S L; Pedroso, I; Kadeva, N et al. (2016) A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. Mol Psychiatry 21:1145-51
Mbarek, Hamdi; Steinberg, Stacy; Nyholt, Dale R et al. (2016) Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. Am J Hum Genet 98:898-908
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69

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