Abstract

A congenic line of mice, on a B6 background, carries a small D2 interval associated with ethanol avoidance in a 2 bottle choice paradigm. Fine mapping of this interval to a 1 cM size is proposed. Recombinant congenic lines will be produced from this small interval to estimate the effect size of the locus, ALCP1. Multiple alcohol-related and other behaviors (possibly associated with high ethanol intake) will be assessed in this congenic strain to determine the pleiotropic effects of this locus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA012301-01A1
Application #
6263228
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Project Start
2001-07-01
Project End
2004-03-31
Budget Start
2001-07-01
Budget End
2002-03-31
Support Year
1
Fiscal Year
2001
Total Cost
$221,100
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Ruf, Cathy; Carosone-Link, Phyllis; Springett, Justin et al. (2004) Confirmation and genetic dissection of a major quantitative trait locus for alcohol preference drinking. Alcohol Clin Exp Res 28:1613-21