Abstract

A congenic line of mice, on a B6 background, carries a small D2 interval associated with ethanol avoidance in a 2 bottle choice paradigm. Fine mapping of this interval to a 1 cM size is proposed. Recombinant congenic lines will be produced from this small interval to estimate the effect size of the locus, ALCP1. Multiple alcohol-related and other behaviors (possibly associated with high ethanol intake) will be assessed in this congenic strain to determine the pleiotropic effects of this locus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA012301-03
Application #
6629495
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Grandison, Lindsey
Project Start
2001-07-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2005-03-31
Support Year
3
Fiscal Year
2003
Total Cost
$220,500
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Ruf, Cathy; Carosone-Link, Phyllis; Springett, Justin et al. (2004) Confirmation and genetic dissection of a major quantitative trait locus for alcohol preference drinking. Alcohol Clin Exp Res 28:1613-21