Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG007591-04
Application #
3118742
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1988-04-01
Project End
1991-12-31
Budget Start
1991-04-01
Budget End
1991-12-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Tang, X C; Kindel, G H; Kozikowski, A P et al. (1994) Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. J Ethnopharmacol 44:147-55
Hanin, I; Tang, X C; Kindel, G L et al. (1993) Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo. Ann N Y Acad Sci 695:304-6
Kozikowski, A P; Miller, C P; Yamada, F et al. (1991) Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. J Med Chem 34:3399-402
McKinney, M; Miller, J H; Yamada, F et al. (1991) Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase. Eur J Pharmacol 203:303-5