This project will examine the impact of the states of alertness (wakefulness, nonrapid eye movement (NREM), and rapid eye movement (REM) sleep), inactivity, and circadian rhythms in elderly who do not have sleep-related respiratory disturbances. With the shift from one state of alertness to another there is a shift in the balance of the autonomic nervous system (ANS), which modulates the activity of many internal organs. A dysfunction of either the ANS or a specific organ may increase physical decline and the risk for early mortality. The aging process appears to disrupt the ANS modulation; resulting dysfunctions may be more apparent and more detrimental in a specific state of alertness. We will study nocturnal ventricular ectopy, frequently associated with coronary artery disease, in elderly subjects who will undergo a 144-hour protocol involving a reversal of day/night sleep patterns.
Our aim i s to determine if sleep states, sleep stages, inactivity, the supine position, and circadian rhythms during the night increase the risk of further dysfunction. With the sleep-reversal protocol, we will dissociate the sleep-related variables from the impact of circadian rhythms to determine which variables pose the greatest risk.
| Kushida, C A; Efron, B; Guilleminault, C (1997) A predictive morphometric model for the obstructive sleep apnea syndrome. Ann Intern Med 127:581-7 |
| Stoohs, R A; Gingold, J; Cohrs, S et al. (1996) Sleep-disordered breathing and systemic hypertension in the older male. J Am Geriatr Soc 44:1295-300 |
| Valencia-Flores, M; Bliwise, D L; Guilleminault, C et al. (1996) Cognitive function in patients with sleep apnea after acute nocturnal nasal continuous positive airway pressure (CPAP) treatment: sleepiness and hypoxemia effects. J Clin Exp Neuropsychol 18:197-210 |
| Stoohs, R A; Facchini, F; Guilleminault, C (1996) Insulin resistance and sleep-disordered breathing in healthy humans. Am J Respir Crit Care Med 154:170-4 |
| Philip, P; Guilleminault, C (1996) Adult psychophysiologic insomnia and positive history of childhood insomnia. Sleep 19:S16-22 |
| Guilleminault, C; Stoohs, R; Kim, Y D et al. (1995) Upper airway sleep-disordered breathing in women. Ann Intern Med 122:493-501 |
| Stoohs, R A; Bingham, L A; Itoi, A et al. (1995) Sleep and sleep-disordered breathing in commercial long-haul truck drivers. Chest 107:1275-82 |
| Guilleminault, C; Clerk, A; Black, J et al. (1995) Nondrug treatment trials in psychophysiologic insomnia. Arch Intern Med 155:838-44 |
| Guilleminault, C; Partinen, M; Hollman, K et al. (1995) Familial aggregates in obstructive sleep apnea syndrome. Chest 107:1545-51 |
| Clerk, A A; Dunan, S R; Guilleminault, C (1994) Load detection in subjects with sleep-induced upper airway obstruction. Am J Respir Crit Care Med 149:727-30 |
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