Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG013789-03
Application #
2653747
Study Section
Immunobiology Study Section (IMB)
Project Start
1996-02-01
Project End
1998-05-31
Budget Start
1998-02-15
Budget End
1998-05-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Dal Porto, Joseph M; Haberman, Ann M; Kelsoe, Garnett et al. (2002) Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med 195:1215-21
Cerasoli, D M; Kelsoe, G; Sarzotti, M (2001) CD4+Thy1- thymocytes with a Th-type 2 cytokine response. Int Immunol 13:75-83
Chen, Z; Koralov, S B; Kelsoe, G (2000) Regulation of humoral immune responses by CD21/CD35. Immunol Rev 176:194-204
Chen, Z; Koralov, S B; Gendelman, M et al. (2000) Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. J Immunol 164:4522-32
Chen, Z; Koralov, S B; Kelsoe, G (2000) Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med 192:1339-52
Takahashi, Y; Cerasoli, D M; Dal Porto, J M et al. (1999) Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med 190:399-410
Yang, K; Davila, M; Kelsoe, G (1999) Do germinal centers have a role in the generation of lymphomas? Curr Top Microbiol Immunol 246:53-60;discussion 61-2
Dal Porto, J M; Haberman, A M; Shlomchik, M J et al. (1998) Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J Immunol 161:5373-81
Takahashi, Y; Dutta, P R; Cerasoli, D M et al. (1998) In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med 187:885-95
Kelsoe, G (1996) The germinal center: a crucible for lymphocyte selection. Semin Immunol 8:179-84