Three defects which have been observed with aging are increased vascular stiffness, depressed responsiveness to catecholamines, and depressed cardiac function. Derangements in adrenergic signaling may presage dysfunction in the cardiac and vascular systems that is induced by the aging process. There are three major components to this study: 1) that altered adrenergic control of vasoactivity precedes increased stiffness in the aged vasculature; 2) that altered adrenergic control of left ventricular (LV) function presages the decline in LV function in the aged heart; and 3) that changes in cardiac and vascular structure in the aging heart are responsible for altered vascular and LV function, but these changes are not necessary for altered adrenergic signaling. To address these components the alterations in arterial pressure/dimension relations, LV function and altered adrenergic signaling with aging will be determined in conscious, chronically instrumented monkeys. The alterations in aging at the cellular and molecular level and histologic alterations in cardiac and vascular structure will be examined. These studies will be conducted in 4 groups of monkeys: 1) younger adults (3-5 years); 2) mature adults (7-10 years); 3) older adults (15-19 years); and 4) senescent adults (older that 20 years).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG014121-05
Application #
6169601
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Program Officer
Dutta, Chhanda
Project Start
1996-09-30
Project End
2002-07-31
Budget Start
2000-09-30
Budget End
2001-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$352,333
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
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