Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
9R01AG014554-05
Application #
2002458
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1992-06-03
Project End
2000-06-30
Budget Start
1996-09-19
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Van Ess, P J; Pedersen, W A; Culmsee, C et al. (2002) Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurochem 80:571-8
Van Ess, Peter J; Mattson, Mark P; Blouin, Robert A (2002) Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment. J Pharmacol Exp Ther 300:824-30
Van Ess, Peter J; Poloyac, Samuel; Mattson, Mark P et al. (2002) Blunted induction of hepatic CYP4A in TNF (p55-/-/p75-/-) double receptor knockout mice following clofibrate treatment. Pharm Res 19:708-12
Warren, G W; van Ess, P J; Watson, A M et al. (2001) Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response. J Interferon Cytokine Res 21:821-6
Guo, Z H; Mattson, M P (2000) Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cereb Cortex 10:50-7
Pedersen, W A; Luo, H; Kruman, I et al. (2000) The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB J 14:913-24
Guo, Q; Fu, W; Holtsberg, F W et al. (1999) Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations. J Neurosci Res 56:457-70
Pedersen, W A; Cashman, N R; Mattson, M P (1999) The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells. Exp Neurol 155:1-10
Begley, J G; Duan, W; Chan, S et al. (1999) Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 72:1030-9
Chan, S L; Tammariello, S P; Estus, S et al. (1999) Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation. J Neurochem 73:502-12

Showing the most recent 10 out of 38 publications