Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG014554-06S1
Application #
2640690
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1992-06-03
Project End
2000-06-30
Budget Start
1997-07-15
Budget End
1998-06-30
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Van Ess, P J; Pedersen, W A; Culmsee, C et al. (2002) Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurochem 80:571-8
Van Ess, Peter J; Mattson, Mark P; Blouin, Robert A (2002) Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment. J Pharmacol Exp Ther 300:824-30
Van Ess, Peter J; Poloyac, Samuel; Mattson, Mark P et al. (2002) Blunted induction of hepatic CYP4A in TNF (p55-/-/p75-/-) double receptor knockout mice following clofibrate treatment. Pharm Res 19:708-12
Warren, G W; van Ess, P J; Watson, A M et al. (2001) Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response. J Interferon Cytokine Res 21:821-6
Guo, Z H; Mattson, M P (2000) Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cereb Cortex 10:50-7
Pedersen, W A; Luo, H; Kruman, I et al. (2000) The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB J 14:913-24
Bruce-Keller, A J; Umberger, G; McFall, R et al. (1999) Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol 45:8-15
Kruman, I I; Pedersen, W A; Springer, J E et al. (1999) ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol 160:28-39
Duan, W; Mattson, M P (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res 57:195-206
Warren, G W; Poloyac, S M; Gary, D S et al. (1999) Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration. J Pharmacol Exp Ther 288:945-50

Showing the most recent 10 out of 38 publications