Dr. Boettcher will conduct a series of experiments to investigate the additivity of age-related and noise-induced hearing loss in the gerbil. Animals will be raised in a sound-isolating environment, and hearing testing will be performed on each ear before and after exposure of a single ear to noise at a level intended to produce a mild hearing loss. Dr. Boettcher will investigate whether susceptibility to noise-induced hearing loss varies as a function of age, and whether a non- traumatic conditioning sound can reduce the magnitude of age- related hearing loss. Dr. Boettcher will measure auditory threshold using auditory brainstem responses, and will also, in a subset of animals, obtain measures of histopathology of the stria vacularis, hair cells and eighth nerve fibers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015705-03
Application #
6372207
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Finkelstein, Judith A
Project Start
1999-06-01
Project End
2004-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
3
Fiscal Year
2001
Total Cost
$193,260
Indirect Cost
Name
Medical University of South Carolina
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Boettcher, Flint A; Emery, Mark (2006) Auditory evoked-potential correlates of decrement detection. Hear Res 212:58-64
Boettcher, Flint A (2002) Susceptibility to acoustic trauma in young and aged gerbils. J Acoust Soc Am 112:2948-55
Hamann, Ingo; Gleich, Otto; Klump, Georg M et al. (2002) Behavioral and evoked-potential thresholds in young and old Mongolian gerbils (Meriones unguiculatus). Hear Res 171:82-95
Boettcher, Flint A; Madhotra, Deepali; Poth, Elizabeth A et al. (2002) The frequency-modulation following response in young and aged human subjects. Hear Res 165:10-8
Boettcher, Flint A (2002) Presbyacusis and the auditory brainstem response. J Speech Lang Hear Res 45:1249-61
Boettcher, F A; Poth, E A; Mills, J H et al. (2001) The amplitude-modulation following response in young and aged human subjects. Hear Res 153:32-42