Dr. Boettcher will conduct a series of experiments to investigate the additivity of age-related and noise-induced hearing loss in the gerbil. Animals will be raised in a sound-isolating environment, and hearing testing will be performed on each ear before and after exposure of a single ear to noise at a level intended to produce a mild hearing loss. Dr. Boettcher will investigate whether susceptibility to noise-induced hearing loss varies as a function of age, and whether a non- traumatic conditioning sound can reduce the magnitude of age- related hearing loss. Dr. Boettcher will measure auditory threshold using auditory brainstem responses, and will also, in a subset of animals, obtain measures of histopathology of the stria vacularis, hair cells and eighth nerve fibers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG015705-06
Application #
6775291
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Finkelstein, Judith A
Project Start
1999-06-01
Project End
2005-05-31
Budget Start
2003-08-01
Budget End
2005-05-31
Support Year
6
Fiscal Year
2003
Total Cost
$199,608
Indirect Cost
Name
University of South Alabama
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
172750234
City
Mobile
State
AL
Country
United States
Zip Code
36688
Boettcher, Flint A; Emery, Mark (2006) Auditory evoked-potential correlates of decrement detection. Hear Res 212:58-64
Boettcher, Flint A (2002) Presbyacusis and the auditory brainstem response. J Speech Lang Hear Res 45:1249-61
Boettcher, Flint A (2002) Susceptibility to acoustic trauma in young and aged gerbils. J Acoust Soc Am 112:2948-55
Hamann, Ingo; Gleich, Otto; Klump, Georg M et al. (2002) Behavioral and evoked-potential thresholds in young and old Mongolian gerbils (Meriones unguiculatus). Hear Res 171:82-95
Boettcher, Flint A; Madhotra, Deepali; Poth, Elizabeth A et al. (2002) The frequency-modulation following response in young and aged human subjects. Hear Res 165:10-8
Boettcher, F A; Poth, E A; Mills, J H et al. (2001) The amplitude-modulation following response in young and aged human subjects. Hear Res 153:32-42