Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG021842-02
Application #
6693315
Study Section
Special Emphasis Panel (ZRG1-SSS-1 (01))
Program Officer
Sierra, Felipe
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$343,075
Indirect Cost
Name
University of Illinois at Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Park, Hyun Jung; Gusarova, Galina; Wang, Zebin et al. (2011) Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med 3:21-34
Petrovic, Vladimir; Costa, Robert H; Lau, Lester F et al. (2010) Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biol Ther 9:1008-16
Park, Hyun Jung; Carr, Janai R; Wang, Zebin et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J 28:2908-18
Chen, Yi-Ju; Dominguez-Brauer, Carmen; Wang, Zebin et al. (2009) A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem 284:30695-707
Wang, I-Ching; Chen, Yi-Ju; Hughes, Douglas E et al. (2008) FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem 283:20770-8
Petrovic, Vladimir; Costa, Robert H; Lau, Lester F et al. (2008) FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem 283:453-60
Park, Hyun Jung; Costa, Robert H; Lau, Lester F et al. (2008) Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol 28:5162-71
Park, H J; Wang, Z; Costa, R H et al. (2008) An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle. Oncogene 27:1696-704
Gusarova, Galina A; Wang, I-Ching; Major, Michael L et al. (2007) A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. J Clin Invest 117:99-111
Tan, Yongjun; Raychaudhuri, Pradip; Costa, Robert H (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol 27:1007-16

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