Abstract

This study application is a secondary analysis of an existing database in response to the Program Announcement, PA-09-265: Secondary Analyses of Existing Data Sets and Stored BioSpecimens to Address Clinical Aging Research Questions (R01) to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database is an accumulation of three studies that prospectively tested older adults for influenza. This data will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccne manufacturing process impacts effectiveness.

Public Health Relevance

This study is a secondary analysis of an existing database to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database, an accumulation of three studies, will be used to determine if the current methodology of test-negative controls will actually contro for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccine manufacturing process impacts effectiveness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG043419-01
Application #
8417869
Study Section
Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section (IRAP)
Program Officer
Salive, Marcel
Project Start
2013-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$319,800
Indirect Cost
$114,800

  Institution

Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Hartman, Lauren; Zhu, Yuwei; Edwards, Kathryn M et al. (2018) Underdiagnosis of Influenza Virus Infection in Hospitalized Older Adults. J Am Geriatr Soc 66:467-472
Talbot, H Keipp; Nian, Hui; Chen, Qingxia et al. (2016) Evaluating the case-positive, control test-negative study design for influenza vaccine effectiveness for the frailty bias. Vaccine 34:1806-9
Dare, Ryan; Zhu, Yuwei; Williams, John V et al. (2016) Detection of influenza by real time RT-PCR is not affected by delays in respiratory specimen processing. J Med Virol 88:1891-5
Chen, Qingxia; Nian, Hui; Zhu, Yuwei et al. (2016) Too many covariates and too few cases? - a comparative study. Stat Med 35:4546-4558
Chen, Qingxia; Griffin, Marie R; Nian, Hui et al. (2015) Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ?50 years. J Infect Dis 211:1045-50
Talbot, H Keipp; Nian, Hui; Zhu, Yuwei et al. (2015) Clinical effectiveness of split-virion versus subunit trivalent influenza vaccines in older adults. Clin Infect Dis 60:1170-5