Abstract

This study proposal is a secondary analysis of an existing database to determine influenza vaccine effectiveness in older adults. Currently the effectiveness of the current influenza vaccine in older adults is unknown and the methodology used to determine that vaccine effectiveness has been called into question. This database is an accumulation of three studies that prospectively tested older adults for influenza and verified influenza vaccination status. This data will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccine manufacturing process impacts effectiveness. This study has the potential to modify current vaccine effectiveness study methodology and to modify influenza vaccines recommendations in older adults.

Public Health Relevance

This study is a secondary analysis of an existing database to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database, an accumulation of three studies, will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccine manufacturing process impacts effectiveness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
6R01AG043419-04
Application #
9293699
Study Section
Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section (IRAP)
Program Officer
Salive, Marcel
Project Start
2013-07-01
Project End
2017-06-30
Budget Start
2016-04-30
Budget End
2017-06-30
Support Year
4
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Hartman, Lauren; Zhu, Yuwei; Edwards, Kathryn M et al. (2018) Underdiagnosis of Influenza Virus Infection in Hospitalized Older Adults. J Am Geriatr Soc 66:467-472
Talbot, H Keipp; Nian, Hui; Chen, Qingxia et al. (2016) Evaluating the case-positive, control test-negative study design for influenza vaccine effectiveness for the frailty bias. Vaccine 34:1806-9
Dare, Ryan; Zhu, Yuwei; Williams, John V et al. (2016) Detection of influenza by real time RT-PCR is not affected by delays in respiratory specimen processing. J Med Virol 88:1891-5
Chen, Qingxia; Nian, Hui; Zhu, Yuwei et al. (2016) Too many covariates and too few cases? - a comparative study. Stat Med 35:4546-4558
Chen, Qingxia; Griffin, Marie R; Nian, Hui et al. (2015) Influenza vaccine prevents medically attended influenza-associated acute respiratory illness in adults aged ?50 years. J Infect Dis 211:1045-50
Talbot, H Keipp; Nian, Hui; Zhu, Yuwei et al. (2015) Clinical effectiveness of split-virion versus subunit trivalent influenza vaccines in older adults. Clin Infect Dis 60:1170-5