The defining neuropathologic lesions of Alzheimer's disease (AD) are amyloid-b plaques and tau neurofibrillary tangles, both of which appear many years before the onset of symptoms of cognitive impairment. The overarching goal of this proposal is to evaluate a novel PET tracer, known as [F18] T807, that detects the tau neurofibrillary tangles. We will address three specific contexts in which tau PET could potentially provide critical information useful in clinical AD research by identifying stages of T807 retention that reflect the levels and extent of PHF tau according to the established Braak staging scheme: 1) The identification of age- associated medial temporal lobe PHF-tau that is consistent with Braak Stage I/II, the slowly accumulating form that begins in the third decade of life, but in later years may possibly correlate with more subtle cognitive capacities or have predictive value for eventual development of impairment, perhaps when combined with biomarker evidence of Ab deposition;2) The identification of a neocortical PHF-tau cut point of positivity that indicates an impaired stage of cognitive and clinical function, which when evaluated as a continuous variable is closely correlated with phenotypic features of the illness;3) A determination of the links between deposition of tau and other biomarkers of AD, including amyloid-b, additional measures of neurodegeneration such as volumetric MRI, CSF tau, and measures of large-scale network disruption measured with fcMRI. This proposal builds on our previous work and existing multidisciplinary collaborations to develop clinically relevant, highly sensitive methods for tracking i) early tau deposition that may be linked to early impairment and ii) neocortical tau deposition that is hypothetically linked to dementia (Aim 1), to illuminate the relationship between more malignant, anatomically specific tau deposition that relates to local and generalized volume loss and network connectivity breakdown (Aim 2), and to relate directly in vivo for the first time the joint evolution of brain tau and amyloid-b deposition throughout the life span (Aim 3).

Public Health Relevance

The proposed research will use PET scans to detect an abnormal form of a brain protein known as tau in living humans; and relate tau pathology to age; brain shrinkage; and cognitive impairment. In addition; the role of these measures of tau in Alzheimer's disease dementia will be explored in AD dementia patients and in normal elderly; in particular to relate tau measures to measures of a different abnormal protein known as amyloid-?. This research has public health impact as it may improve our ability to identify transitional stages between normal aging and Alzheimer's disease dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG046396-01
Application #
8612866
Study Section
Clinical Neuroscience and Neurodegeneration Study Section (CNN)
Program Officer
Hsiao, John
Project Start
2014-06-01
Project End
2019-02-28
Budget Start
2014-06-01
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$712,125
Indirect Cost
$302,858
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Makaretz, Sara J; Quimby, Megan; Collins, Jessica et al. (2018) Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. J Neurol Neurosurg Psychiatry 89:1024-1031
Lois, Cristina; Gonzalez, Ivan; Johnson, Keith A et al. (2018) PET imaging of tau protein targets: a methodology perspective. Brain Imaging Behav :
d'Oleire Uquillas, Federico; Jacobs, Heidi I L; Biddle, Kelsey D et al. (2018) Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry 8:282
Jacobs, Heidi I L; Hedden, Trey; Schultz, Aaron P et al. (2018) Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci 21:424-431
Hanseeuw, Bernard J; Betensky, Rebecca A; Mormino, Elizabeth C et al. (2018) PET staging of amyloidosis using striatum. Alzheimers Dement 14:1281-1292
Lee, Christopher M; Jacobs, Heidi I L; Marquié, Marta et al. (2018) 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis 62:1691-1702
Gatchel, Jennifer R; Donovan, Nancy J; Locascio, Joseph J et al. (2017) Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. J Alzheimers Dis 59:975-985
Buckley, Rachel F; Hanseeuw, Bernard; Schultz, Aaron P et al. (2017) Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global ?-Amyloid Burden. JAMA Neurol 74:1455-1463
LaPoint, Molly R; Chhatwal, Jasmeer P; Sepulcre, Jorge et al. (2017) The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage 157:612-622
Xia, Chenjie; Makaretz, Sara J; Caso, Christina et al. (2017) Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol 74:427-436

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