Abstract

The overall objective of this project is to examine the biological implications of the interaction between the acute phase C-reactive protein (CRP) and phospholipids (P L). To accomplish this goal we are investigating: a) The nature of the interaction between CRP and PL in both artificial and natural membranes as well as in serum lipoproteins, b) The effects of these interactions on the properties of the membranes and c) The contribution of these interactions on the ability of CRP to modulate humoral and cellular effector systems of inflammation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015607-07
Application #
3126268
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1979-01-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Szalai, A J; Agrawal, A; Greenhough, T J et al. (1999) C-reactive protein: structural biology and host defense function. Clin Chem Lab Med 37:265-70
Szalai, A J; van Ginkel, F W; Dalrymple, S A et al. (1998) Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice. J Immunol 160:5294-9
Agrawal, A; Lee, S; Carson, M et al. (1997) Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67. J Immunol 158:345-50
Szalai, A J; Briles, D E; Volanakis, J E (1996) Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae. Infect Immun 64:4850-3
Szalai, A J; Briles, D E; Volanakis, J E (1995) Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J Immunol 155:2557-63
Agrawal, A; Volanakis, J E (1994) Probing the C1q-binding site on human C-reactive protein by site-directed mutagenesis. J Immunol 152:5404-10
Agrawal, A; Xu, Y; Ansardi, D et al. (1992) Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis. J Biol Chem 267:25353-8
Kilpatrick, J M; Gresham, H D; Griffin Jr, F M et al. (1987) Peripheral blood mononuclear leukocytes release a mediator(s) that induces phagocytosis of C-reactive protein-coated cells by polymorphonuclear leukocytes. J Leukoc Biol 41:150-5
Horowitz, J; Volanakis, J E; Briles, D E (1987) Blood clearance of Streptococcus pneumoniae by C-reactive protein. J Immunol 138:2598-603
Gresham, H D; Clement, L T; Volanakis, J E et al. (1987) Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2. J Immunol 139:4159-66

Showing the most recent 10 out of 13 publications