Abstract

This project proposes to maintain a colony of mice bearing histocompatibility gene mutations, particular those of the H-2 complex, as a resource colony. Incipient mutant strains, currently under development, will be completed and added to the collection. Strains maintained will be systematically monitored to maintain their genetic integrity, by skin grafting and by serological typing. No further large scale screening by skin grafting, for new mutants will be carried out as part of this project. however, additional future mutants may be added as recovered from another separately funded project in which skin grafting is used to monitor the genetic integrity of the NCI mouse colonies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI016919-11
Application #
3126893
Study Section
Immunobiology Study Section (IMB)
Project Start
1979-09-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
School of Medicine & Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Wang, K; Busker-Mannie, A E; Hoeft, J et al. (2001) Prolonged Hya-disparate skin graft survival in ethanol-consuming mice: correlation with impaired delayed hypersensitivity. Alcohol Clin Exp Res 25:1542-8
Yun, T J; Melvold, R W; Pease, L R (1997) A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice. Proc Natl Acad Sci U S A 94:1384-9
Makino, M; Murphy, D B; Melvold, R W et al. (1995) Impact of MHC class I gene on resistance to murine AIDS. Scand J Immunol 42:368-72
Rubocki, R J; Connolly, J M; Hansen, T H et al. (1991) Mutation at amino acid position 133 of H-2Dd prevents beta 2m association and immune recognition but not surface expression. J Immunol 146:2352-7
Busker, A E; Miller, S D; Melvold, R W (1990) Induction of allograft tolerance to the H-Y antigen in adult C57BL/6 mice: differential effects on delayed-type hypersensitivity and cytolytic T-lymphocyte activity. Cell Immunol 125:225-34
Melvold, R W; Jokinen, D M; Miller, S D et al. (1990) Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 64:686-90
Melvold, R W; Jokinen, D M; Knobler, R L et al. (1987) Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromos J Immunol 138:1429-33
Colombo, M P; Melvold, R W; Wettstein, P J (1987) Inheritance of a mutant histocompatibility gene and a new mammary tumor virus genome in the B6.KH-84 mouse strain. Immunogenetics 26:99-104
Stuart, P M; Iannaccone, P M; Miller, S D et al. (1987) In vitro and in vivo correlates of hybrid tumor resistance. J Natl Cancer Inst 78:1159-68
Wettstein, P J; Melvold, R W (1986) Xenotropic virus-related restriction patterns of non-H-2 histocompatibility mutant mice strains. Immunogenetics 23:156-63

Showing the most recent 10 out of 11 publications