The objective of the proposed research is the total synthesis of the novel antibiotic bicyclomycin in optically active form and of select bicyclomycin analogs to be used in evaluating the chemical mechanism of antibacterial action of bicyclomycin. New synthetic methods for constructing the bicyclomycin ring system will be investigated. The synthetic strategem is of sufficient bravity and versatility to allow the elaboration of bicyclomycin and all synthetic analogs from a few common intermediates. By these methods, the chemical structural and dynamic properties of the bicyclomycin ring system as a """"""""latent"""""""" Alpha,Beta-unsaturated pryuvamide (Michael acceptor) will be investigated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018957-06
Application #
3128351
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-05-01
Project End
1988-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Type
Schools of Arts and Sciences
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523