Abstract

The overall objective of the work proposed is to determine how IgA production is regulated in mice. We plan to determine whether the differentiation of bone marrow derived (B) cells into IgA producing plasma cells is regulated by special subsets of thymus-derived T cells, uniquely adapted for interaction with IgA precursor B cells, either by recognition of such cells or by preference for the same lymphoid organs, i.e., the gut-associated lymphoid tissue (GALT), or whether any T helper (Th) and T suppressor (Ts) cells of the appropriate carrier specificity will do. We shall examine the possibility that special T cells or non-lymphoid elements of GALT, specifically Peyer's patches, provide a differentiation signal, necessary for the differentiation of B cells, bearing mu and/or delta chains, to IgA production. We shall probe the question of whether there can be a secondary IgA response (i.e., whether there are IgA memory B cells) and whether there are T dependent and T independent antigens capable of stimulating IgA production. We shall attempt to determine how the selective migration of different populations of B and T lymphocytes into different lymphoid organs is controlled.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020786-17
Application #
3130614
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1984-01-01
Project End
1986-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
17
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Phillips-Quagliata, J M; Rao, T D; Maghazachi, A A et al. (1992) The IgA receptors of T560, a murine IL-4-secreting, CD5-, IgG2A kappa+, BrMRBC-binding B lymphoma. Ann N Y Acad Sci 651:491-3
Rao, T D; Maghazachi, A A; Faria, A M et al. (1992) T560: an (H-2b x H-2a) F1 hybrid, phosphorylcholine (PC)-binding, murine B cell lymphoma that bears receptors for IgA and IgG, presents antigen and secretes IL-4. Int Immunol 4:107-18
Phillips-Quagliata, J M; Rao, T D; Maghazachi, A A et al. (1991) Sensitivity of receptors for IgA on T560, a murine B lymphoma, to phorbol myristate acetate and to phosphatidylinositol-specific phospholipase C. Immunol Res 10:432-6
Maghazachi, A A; Phillips-Quagliata, J M (1988) Con A-propagated, auto-reactive T cell clones that secrete factors promoting high IgA responses. Int Arch Allergy Appl Immunol 86:147-56
Phillips-Quagliata, J M; Maghazachi, A A (1987) T cell clones that help IgA responses. Adv Exp Med Biol 216A:101-17