Recently, procedures have been developed for the selective enrichment (positive selection) and depletion (negative selection) of alloantigen-reactive lymphocytes. These procedures will be applied to two questions concerning the biological function of gene products of the major histocompatibility complex (MHC) and the high frequency of MHC alloantigen reactive T lymphocytes: (1) The extent of involvement of MHC gene products in the induction and expression of certain T cell mediated immune functions, namely cytotoxicity, delayed-type hypersensitivity and helper responses for B cells; and (2) the possible involvement of anti-MHC receptors present on the majority of T cells in the specificity of triggering with conventional antigens. These questions have a direct bearing on the mechanisms of T-cell stimulation by antigen and whether T cells possess multiple specificities for antigen.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022519-02
Application #
3133685
Study Section
Immunobiology Study Section (IMB)
Project Start
1985-01-01
Project End
1987-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Medical Biology Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037