Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI024431-12
Application #
2404052
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1990-04-01
Project End
1998-06-30
Budget Start
1998-04-01
Budget End
1998-06-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Obrig, Tom G; Karpman, Diana (2012) Shiga toxin pathogenesis: kidney complications and renal failure. Curr Top Microbiol Immunol 357:105-36
Fujii, Jun; Naito, Mariko; Yutsudo, Takashi et al. (2012) Protection by a recombinant Mycobacterium bovis Bacillus Calmette-Guerin vaccine expressing Shiga toxin 2 B subunit against Shiga toxin-producing Escherichia coli in mice. Clin Vaccine Immunol 19:1932-7
Obata, Fumiko; Obrig, Tom (2010) Distribution of Gb(3) Immunoreactivity in the Mouse Central Nervous System. Toxins (Basel) 2:1997-2006
Obrig, Tom G (2010) Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease. Toxins (Basel) 2:2769-2794
Psotka, Mitchell A; Obata, Fumiko; Kolling, Glynis L et al. (2009) Shiga toxin 2 targets the murine renal collecting duct epithelium. Infect Immun 77:959-69
Obata, Fumiko; Tohyama, Koujiro; Bonev, Adrian D et al. (2008) Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J Infect Dis 198:1398-406
Roche, James K; Stone, Matthew K; Gross, Lisa K et al. (2008) Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model. Lab Invest 88:1178-91
Roche, James K; Keepers, Tiffany R; Gross, Lisa K et al. (2007) CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli O157:H7-associated renal inflammation. Am J Pathol 170:526-37
Louise, C B; Obrig, T G (1994) Human renal microvascular endothelial cells as a potential target in the development of the hemolytic uremic syndrome as related to fibrinolysis factor expression, in vitro. Microvasc Res 47:377-87
Obrig, T G; Louise, C B; Moran, T P et al. (1993) Direct cytotoxic effects of hemorrhagic toxins from Crotalus ruber ruber and Crotalus atrox on human vascular endothelial cells, in vitro. Microvasc Res 46:412-6