The purpose of this study is to elucidate the pathogenesis of FIV infection in cats starting with the transient primary stage of disease, encompassing the subsequent protracted latent stage of disease, and terminating with the death of animals from AIDS-like disease or other lentivirus-related conditions. The ultimate goal of the research is to demonstrate parallels between HIV infection of man and FIV infection of the cat and, in so doing, to validate FIV infection as a model for the study of human AIDS.
The specific aims of the application are studies on the pathogenesis of FIV infection which involve observing the evolution of FIV-induced disease in specific pathogen-free (SPF) cats housed under pathogen-free conditions. Also, the applicant proposes to study co-factors which might accelerate or potentiate FIV-induced disease such as the cattery environment in general and any incidental infectious diseases. The investigator will attempt to define the significance of sero-negative FIV-infected cats (occult carriers?) and to localize viral DNA, RNA, and antigens at various stages of infection and disease. He will also try to define the relationship of naturally- and experimentally-induced FIV infection and cancer and to determine if FIV infection of newborn kittens can serve as a model for pediatric AIDS.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
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Special Emphasis Panel (ARR (V1))
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University of California Davis
Schools of Veterinary Medicine
United States
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George, Jeanne W; Rideout, Bruce A; Griffey, Stephen M et al. (2002) Effect of preexisting FeLV infection or FeLV and feline immunodeficiency virus coinfection on pathogenicity of the small variant of Haemobartonella felis in cats. Am J Vet Res 63:1172-8
Lappin, M R; George, J W; Pedersen, N C et al. (1996) Primary and secondary Toxoplasma gondii infection in normal and feline immunodeficiency virus-infected cats. J Parasitol 82:733-42
Dean, G A; Reubel, G H; Moore, P F et al. (1996) Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node. J Virol 70:5165-9
Rimstad, E; Reubel, G H; Dean, G A et al. (1995) Cloning, expression and characterization of biologically active feline tumour necrosis factor-alpha. Vet Immunol Immunopathol 45:297-310
Reubel, G H; George, J W; Higgins, J et al. (1994) Effect of chronic feline immunodeficiency virus infection on experimental feline calicivirus-induced disease. Vet Microbiol 39:335-51
Sparger, E E; Beebe, A M; Dua, N et al. (1994) Infection of cats with molecularly cloned and biological isolates of the feline immunodeficiency virus. Virology 205:546-53
Reubel, G H; Dean, G A; George, J W et al. (1994) Effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats. J Acquir Immune Defic Syndr 7:1003-15
Dua, N; Reubel, G; Moore, P F et al. (1994) An experimental study of primary feline immunodeficiency virus infection in cats and a historical comparison to acute simian and human immunodeficiency virus diseases. Vet Immunol Immunopathol 43:337-55
Reubel, G H; Ramos, R A; Hickman, M A et al. (1993) Detection of active and latent feline herpesvirus 1 infections using the polymerase chain reaction. Arch Virol 132:409-20
George, J W; Pedersen, N C; Higgins, J (1993) The effect of age on the course of experimental feline immunodeficiency virus infection in cats. AIDS Res Hum Retroviruses 9:897-905

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