Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI025836-08
Application #
2063112
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1988-03-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Kavita, U; Mizel, S B (1995) Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease. J Biol Chem 270:27758-65
Siders, W M; Mizel, S B (1995) Interleukin-1 beta secretion. A possible multistep process that is regulated in a cell type-specific manner. J Biol Chem 270:16258-64
Siders, W M; Klimovitz, J C; Mizel, S B (1993) Characterization of the structural requirements and cell type specificity of IL-1 alpha and IL-1 beta secretion. J Biol Chem 268:22170-4
Lord, P C; Wilmoth, L M; Mizel, S B et al. (1991) Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes. J Clin Invest 87:1312-21
Carruth, L M; Demczuk, S; Mizel, S B (1991) Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor. J Biol Chem 266:12162-7
Suttles, J; Giri, J G; Mizel, S B (1990) IL-1 secretion by macrophages. Enhancement of IL-1 secretion and processing by calcium ionophores. J Immunol 144:175-82
Suttles, J; Carruth, L M; Mizel, S B (1990) Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes. Evidence against a membrane form of IL-1. J Immunol 144:170-4
Mizel, S B (1989) The interleukins. FASEB J 3:2379-88
Minnich-Carruth, L L; Suttles, J; Mizel, S B (1989) Evidence against the existence of a membrane form of murine IL-1 alpha. J Immunol 142:526-30
Shirakawa, F; Mizel, S B (1989) In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424-30

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