Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026950-08
Application #
2063675
Study Section
Experimental Immunology Study Section (EI)
Project Start
1989-03-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pathology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Jensen, P L; Mescher, M F (2001) Role of phosphoinositide 3-kinase in TCR-signaled regulation of CD8-mediated adhesion to class I MHC protein. Eur J Immunol 31:3612-21
Ni, H T; Deeths, M J; Li, W et al. (1999) Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation. J Immunol 162:5183-9
Ni, H T; Deeths, M J; Mescher, M F (1996) Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells. J Immunol 157:2243-6
Anel, A; O'Rourke, A M; Kleinfeld, A M et al. (1996) T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: activation of p56lck by CD8 binding to class I protein. Eur J Immunol 26:2310-9
Anel, A; Mescher, M F; Kleinfeld, A M (1995) Activated adhesion of CTL to MHC class I but not to fibronectin is inhibited by cis unsaturated fatty acids and phenylarsine oxide. J Immunol 155:1039-46
O'Rourke, A M; Mescher, M F (1994) Signals for activation of CD8-dependent adhesion and costimulation in CTLs. J Immunol 152:4358-67
O'Rourke, A M; Ybarrondo, B; Mescher, M F (1993) CD8 and antigen-specific T cell adhesion cascades. Semin Immunol 5:263-70
O'Rourke, A M; Mescher, M F; Apgar, J R (1992) IgE receptor-mediated arachidonic acid release by rat basophilic leukemia (RBL-2H3) cells: possible role in activating degranulation. Mol Immunol 29:1299-308
Mescher, M F (1992) Surface contact requirements for activation of cytotoxic T lymphocytes. J Immunol 149:2402-5
Apgar, J R (1991) Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C. J Cell Biol 112:1157-63

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