Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI027568-05
Application #
2063945
Study Section
Immunobiology Study Section (IMB)
Project Start
1989-09-30
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Genetics
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Hoerter, John A H; Brzostek, Joanna; Artyomov, Maxim N et al. (2013) Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med 210:1807-21
Wang, Baomei; Primeau, Tina M; Myers, Nancy et al. (2009) A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire. Science 326:871-4
Truscott, Steven M; Wang, Xiaoli; Lybarger, Lonnie et al. (2008) Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides. J Biol Chem 283:7480-90
Mitaksov, Vesselin; Truscott, Steven M; Lybarger, Lonnie et al. (2007) Structural engineering of pMHC reagents for T cell vaccines and diagnostics. Chem Biol 14:909-22
Truscott, Steven M; Lybarger, Lonnie; Martinko, John M et al. (2007) Disulfide bond engineering to trap peptides in the MHC class I binding groove. J Immunol 178:6280-9
Primeau, Tina; Myers, Nancy B; Yu, Y Y Lawrence et al. (2005) Applications of major histocompatibility complex class I molecules expressed as single chains. Immunol Res 32:109-21
Lybarger, Lonnie; Yu, Y Y Lawrence; Miley, Michael J et al. (2003) Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide. J Biol Chem 278:27105-11
Hornell, Tara M C; Myers, Nancy; Hansen, Ted H et al. (2003) Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity. J Immunol 170:4506-14
Yu, Yik Y L; Netuschil, Nikolai; Lybarger, Lonnie et al. (2002) Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells. J Immunol 168:3145-9
Hornell, T M; Martin, S M; Myers, N B et al. (2001) Peptide length variants p2Ca and QL9 present distinct conformations to L(d)-specific T cells. J Immunol 167:4207-14

Showing the most recent 10 out of 23 publications