Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI027976-06
Application #
2064220
Study Section
Experimental Immunology Study Section (EI)
Project Start
1990-01-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Pride, M W; Bailey, C R; Muchmore, E et al. (1998) Evaluation of B and T-cell responses in chimpanzees immunized with Hepagene, a hepatitis B vaccine containing pre-S1, pre-S2 gene products. Vaccine 16:543-50
Thanavala, Y (1996) Novel approaches to vaccine development against HBV. J Biotechnol 44:67-73
Thanavala, Y; Yang, Y F; Lyons, P et al. (1995) Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc Natl Acad Sci U S A 92:3358-61
Rajadhyaksha, M M; Thanavala, Y M (1995) Differential antigen presentation of hepatitis B surface antigen on cell membranes of responder and nonresponder mice. Tissue Antigens 45:188-96
Rajadhyaksha, M; Yang, Y F; Thanavala, Y M (1995) Immunological evaluation of three generations of anti-idiotype vaccine: study of B and T cell responses following priming with anti-idiotype, anti-idiotype peptide and its MAP structure. Vaccine 13:1421-6
Rajadhyaksha, M; Thanavala, Y (1995) Delineation of the minimal hepatitis B surface antigen-specific B- and T-cell epitope contained within an anti-idiotype-derived pentadecapeptide. Proc Natl Acad Sci U S A 92:1575-9
Yang, Y F; Thanavala, Y (1995) A comparison of the antibody and T cell response elicited by internal image and noninternal image anti-idiotypes. Clin Immunol Immunopathol 75:154-8
Pride, M W; Thakur, A; Thanavala, Y (1993) Mimicry of the a determinant of hepatitis B surface antigen by an antiidiotypic antibody. I. Evaluation in hepatitis B surface antigen responder and nonresponder strains. J Exp Med 177:127-34
Pride, M W; Shi, H; Anchin, J M et al. (1992) Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide. Proc Natl Acad Sci U S A 89:11900-4
Neurath, A R; Pride, M W; Strick, N et al. (1990) Toleration of amino acid substitutions within hepatitis B virus envelope protein epitopes established by peptide replacement set analysis. I. Region S(139-147). Pept Res 3:116-22