Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI031802-06
Application #
2330366
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1992-02-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Hoque, Mainul; Tian, Bin; Mathews, Michael B et al. (2005) Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J Biol Chem 280:13648-57
Reza, Syed M; Shen, Lin-Ming; Mukhopadhyay, Rupa et al. (2003) A naturally occurring substitution in human immunodeficiency virus Tat increases expression of the viral genome. J Virol 77:8602-6
Hoque, Mainul; Young, Tara M; Lee, Chee-Gun et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol 23:1688-702
Young, Tara M; Wang, Qi; Pe'ery, Tsafi et al. (2003) The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol 23:6373-84
Reza, Syed M; Rosetti, Mihaela; Mathews, Michael B et al. (2003) Differential activation of Tat variants in mitogen-stimulated cells: implications for HIV-1 postintegration latency. Virology 310:141-56
Ramanathan, Y; Rajpara, S M; Reza, S M et al. (2001) Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. J Biol Chem 276:10913-20
Ramanathan, Y; Reza, S M; Young, T M et al. (1999) Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate. J Virol 73:5448-58
Gunnery, S; Ma, Y; Mathews, M B (1999) Termination sequence requirements vary among genes transcribed by RNA polymerase III. J Mol Biol 286:745-57
Greenberg, M E; Mathews, M B (1997) Effects of heterologous downstream sequences on the activity of the HIV-1 promoter and its response to Tat. Nucleic Acids Res 25:5017-24
Pe'ery, T; Mathews, M B (1997) Synthesis and purification of single-stranded RNA for use in experiments with PKR and in cell-free translation systems. Methods 11:371-81

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