Development of Ribozymes to Control RNA Virus Infection

Whitton, J. Lindsay

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI032935-04
• Application #: 2067862
• Study Section: Virology Study Section (VR)
• Project Start: 1993-04-01
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Gebhard, J R; Perry, C M; Mahadeviah, S et al. (1997) Use of a nonviral vector to express a chimeric tRNA-ribozyme against lymphocytic choriomeningitis virus: cytoplasmic accumulation of a catalytically competent transcript but minimal antiviral effect. Antisense Nucleic Acid Drug Dev 7:3-11

Yokoyama, M; Zhang, J; Whitton, J L (1996) DNA immunization: effects of vehicle and route of administration on the induction of protective antiviral immunity. FEMS Immunol Med Microbiol 14:221-30

Xing, Z; Mahadeviah, S; Whitton, J L (1995) Antiviral activity of RNA molecules containing self-releasing ribozymes targeted to lymphocytic choriomeningitis virus. Antisense Res Dev 5:203-12

Whitton, J L (1994) Antisense treatment of viral infection. Adv Virus Res 44:267-303