Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033525-03
Application #
2068578
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-07-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817

  Publications

Ikeda, J S; Schmitt, C K; Darnell, S C et al. (2001) Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis. Infect Immun 69:3021-30
Schmitt, C K; Ikeda, J S; Darnell, S C et al. (2001) Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis. Infect Immun 69:5619-25
Gewirtz, A T; Simon Jr, P O; Schmitt, C K et al. (2001) Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J Clin Invest 107:99-109
Schmitt, C K; Meysick, K C; O'Brien, A D (1999) Bacterial toxins: friends or foes? Emerg Infect Dis 5:224-34
Schmitt, C K; Darnell, S C; O'Brien, A D (1996) The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species. FEMS Microbiol Lett 135:281-5
Schmitt, C K; Darnell, S C; O'Brien, A D (1996) The attenuated phenotype of a Salmonella typhimurium flgM mutant is related to expression of FliC flagellin. J Bacteriol 178:2911-5
Schmitt, C K; Darnell, S C; Tesh, V L et al. (1994) Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype. J Bacteriol 176:368-77