Abstract

The primary objective of this proposal is to determine the propensity of silicone-gel to induce an auto-immune syndrome in an animal model system. To this end we have proposed a three step approach: 1. animal testing to determine the relative risk of silicone-gel/oil of inducing an auto-immune syndrome. 2. In-vitro testing of silicone-gel/oil capacity to activate macrophages. 3. Physicochemical testing of the silicone-gel/oil. Steps 2 and 3 will aid in our understanding of the adjuvant properties of silicones and a better understanding of adjuvancy in general and lead to the development of safer biological implants. The health relatedness of these studies will aid in determining the risk of developing an auto- immune ailment in women who have received silicone-gel filled mammary implants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034597-03
Application #
2069760
Study Section
Experimental Immunology Study Section (EI)
Project Start
1993-09-01
Project End
1998-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Rochester General Hospital (NY)
Department
Type
DUNS #
City
Rochester
State
NY
Country
United States
Zip Code
14621

  Publications

Marks, Matthew; Burns, Tamika; Abadi, Maria et al. (2007) Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun 75:1586-97
Naim, J O; Satoh, M; Buehner, N A et al. (2000) Induction of hypergammaglobulinemia and macrophage activation by silicone gels and oils in female A.SW mice. Clin Diagn Lab Immunol 7:366-70
Naim, J O; Ippolito, K M; van Oss, C J (1997) Adjuvancy effect of different types of silicone gel. J Biomed Mater Res 37:534-8
Naim, J O; van Oss, C J; Wu, W et al. (1997) Mechanisms of adjuvancy: I--Metal oxides as adjuvants. Vaccine 15:1183-93
van Oss, C J (1997) Kinetics and energetics of specific intermolecular interactions. J Mol Recognit 10:203-16
van Oss, C J; Naim, J O (1996) Aspecific immunoglobulin binding to hydrophobic surfaces. Curr Top Microbiol Immunol 210:85-91
Naim, J O; Ippolito, K M; Lanzafame, R J et al. (1996) Induction of type II collagen arthritis in the DA rat using silicone gel as adjuvant. Curr Top Microbiol Immunol 210:103-11
Naim, J O; Ippolito, K M; Lanzafame, R J (1995) The effect of molecular weight and gel preparation on humoral adjuvancy of silicone oils and silicone gels. Immunol Invest 24:537-47
Naim, J O; Ippolito, K M; Lanzafame, R J et al. (1995) Induction of type II collagen arthritis in the DA rat using silicone gels and oils as adjuvant. J Autoimmun 8:751-61
Naim, J O; Lanzafame, R J; van Oss, C J (1995) The effect of silicone-gel on the immune response. J Biomater Sci Polym Ed 7:123-32

Showing the most recent 10 out of 12 publications