Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035955-03
Application #
2071952
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1994-09-01
Project End
1998-03-31
Budget Start
1996-09-01
Budget End
1998-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Montreal General Hospital
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
Stevenson, M M; Su, Z; Sam, H et al. (2001) Modulation of host responses to blood-stage malaria by interleukin-12: from therapy to adjuvant activity. Microbes Infect 3:49-59
Sam, H; Stevenson, M M (1999) In vivo IL-12 production and IL-12 receptors beta1 and beta2 mRNA expression in the spleen are differentially up-regulated in resistant B6 and susceptible A/J mice during early blood-stage Plasmodium chabaudi AS malaria. J Immunol 162:1582-9
Sam, H; Su, Z; Stevenson, M M (1999) Deficiency in tumor necrosis factor alpha activity does not impair early protective Th1 responses against blood-stage malaria. Infect Immun 67:2660-4
Mohan, K; Sam, H; Stevenson, M M (1999) Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection. Infect Immun 67:513-9
Sam, H; Stevenson, M M (1999) Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria. Clin Exp Immunol 117:343-9
Mohan, K; Stevenson, M M (1998) Dyserythropoiesis and severe anaemia associated with malaria correlate with deficient interleukin-12 production. Br J Haematol 103:942-9
Mohan, K; Stevenson, M M (1998) Interleukin-12 corrects severe anemia during blood-stage Plasmodium chabaudi AS in susceptible A/J mice. Exp Hematol 26:45-52
Mohan, K; Moulin, P; Stevenson, M M (1997) Natural killer cell cytokine production, not cytotoxicity, contributes to resistance against blood-stage Plasmodium chabaudi AS infection. J Immunol 159:4990-8
Jacobs, P; Radzioch, D; Stevenson, M M (1996) In vivo regulation of nitric oxide production by tumor necrosis factor alpha and gamma interferon, but not by interleukin-4, during blood stage malaria in mice. Infect Immun 64:44-9
Stevenson, M M; Tam, M F; Wolf, S F et al. (1995) IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism. J Immunol 155:2545-56