Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI035990-01S1
Application #
2072008
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1994-09-30
Project End
1997-08-31
Budget Start
1994-09-30
Budget End
1995-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Holler, Phillip D; Kranz, David M (2004) T cell receptors: affinities, cross-reactivities, and a conformer model. Mol Immunol 40:1027-31
Brophy, Susan E; Holler, Phillip D; Kranz, David M (2003) A yeast display system for engineering functional peptide-MHC complexes. J Immunol Methods 272:235-46
Chen, Jianzhu; Eisen, Herman N; Kranz, David M (2003) A model T-cell receptor system for studying memory T-cell development. Microbes Infect 5:233-40
Orr, Brent A; Carr, Lori M; Wittrup, K Dane et al. (2003) Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnol Prog 19:631-8
Starwalt, Scott E; Masteller, Emma L; Bluestone, Jeffrey A et al. (2003) Directed evolution of a single-chain class II MHC product by yeast display. Protein Eng 16:147-56
Holler, P D; Lim, A R; Cho, B K et al. (2001) CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation. J Exp Med 194:1043-52
VanAntwerp, J J; Wittrup, K D (2000) Fine affinity discrimination by yeast surface display and flow cytometry. Biotechnol Prog 16:31-7
Griffin, M D; Hong, D K; Holman, P O et al. (2000) Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152). J Immunol 164:4433-42
Kranz, D M; Manning, T C; Rund, L A et al. (1998) Targeting tumor cells with bispecific antibodies and T cells. J Control Release 53:77-84
Patrick, T A; Kranz, D M; Zachary, J F et al. (1998) Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors. Int J Cancer 78:470-9

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