Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036872-03
Application #
2073377
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1994-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Ptak, Roger G; Gentry, Brian G; Hartman, Tracy L et al. (2010) Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef. Antimicrob Agents Chemother 54:1512-9
Migawa, Michael T; Drach, John C; Townsend, Leroy B (2005) Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7 J Med Chem 48:3840-51
Porcari, Anthony R; Townsend, Leroy B (2004) An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. Nucleosides Nucleotides Nucleic Acids 23:31-9
Porcari, Anthony R; Ptak, Roger G; Borysko, Katherine Z et al. (2003) Synthesis and antiviral activity of 2-substituted analogs of triciribine. Nucleosides Nucleotides Nucleic Acids 22:2171-93
Migawa, M T; Townsend, L B (2001) Synthesis and unusual chemical reactivity of certain novel 4,5-disubstituted 7-benzylpyrrolo[2,3-d][1,2,3]triazines. J Org Chem 66:4776-82
Liu, W; Wise, D S; Townsend, L B (2001) Dimetalation of pyrazines. a one-pot synthesis of multisubstituted pyrazine C-nucleosides. J Org Chem 66:4783-6
Porcari, A R; Ptak, R G; Borysko, K Z et al. (2000) 6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1. J Med Chem 43:2457-63
Porcari, A R; Ptak, R G; Borysko, K Z et al. (2000) Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation. J Med Chem 43:2438-48
Qiu, Y L; Geiser, F; Kira, T et al. (2000) Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells. Antivir Chem Chemother 11:191-202
Porcari, A R; Townsend, L B (1999) Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures. Nucleosides Nucleotides 18:153-9

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