Abstract

EXCEED THE SPACE PROVIDED. PERFORMANCE SITE(S) (organization, city, state) KEY PERSONNEL. See instructions on Page 11. Use continuation pages as needed to provide the required information in the format shown below. Name Organization . Role on Project Mark S. Klempner, M.D. BMC Principal Investigator Linden Hu, M.D. BMC Co-Investigator Bo Lin,Ph.D. BMC Post-Doctoral Fellow PHS 398 (Rev. 4/98) Do not page number this form ========================================Section End===========================================

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI037241-10
Application #
6897967
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Baker, Phillip J
Project Start
1994-09-30
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2007-06-30
Support Year
10
Fiscal Year
2005
Total Cost
$402,500
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Zhao, Zhihui; Fleming, Rhonda; McCloud, Bilaal et al. (2007) CD14 mediates cross talk between mononuclear cells and fibroblasts for upregulation of matrix metalloproteinase 9 by Borrelia burgdorferi. Infect Immun 75:3062-9
Zhao, Zhihui; McCloud, Bilaal; Fleming, Rhonda et al. (2007) Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. Biochem Biophys Res Commun 358:528-33
Fleming, R V; Marques, A R; Klempner, M S et al. (2004) Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis. Eur J Clin Microbiol Infect Dis 23:615-8
Wang, Xing-Guo; Kidder, J Michael; Scagliotti, Joanna P et al. (2004) Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon. J Bacteriol 186:51-60
Zhao, Zhihui; Chang, Hernan; Trevino, Richard P et al. (2003) Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute lyme disease. J Infect Dis 188:1098-104
Lin, B; Kidder, J M; Noring, R et al. (2001) Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment. J Infect Dis 184:174-80
Lin, B; Short, S A; Eskildsen, M et al. (2001) Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(-) Escherichia coli. Biochim Biophys Acta 1499:222-31
Perides, G; Tanner-Brown, L M; Eskildsen, M A et al. (1999) Borrelia burgdorferi induces matrix metalloproteinases by neural cultures. J Neurosci Res 58:779-90
Perides, G; Charness, M E; Tanner, L M et al. (1998) Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis. J Infect Dis 177:401-8
Hu, L T; Klempner, M S (1997) Host-pathogen interactions in the immunopathogenesis of Lyme disease. J Clin Immunol 17:354-65

Showing the most recent 10 out of 15 publications