Modifying HIV to Integrate at Preselected DNA Sites

Bushman, Frederic D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI037489-02
• Application #: 2074243
• Study Section: AIDS and Related Research Study Section 3 (ARRC)
• Project Start: 1994-12-01
• Project End: 1996-11-30
• Budget Start: 1995-12-01
• Budget End: 1996-11-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Salk Institute for Biological Studies
• DUNS #: 005436803
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Li, L; Farnet, C M; Anderson, W F et al. (1998) Modulation of activity of Moloney murine leukemia virus preintegration complexes by host factors in vitro. J Virol 72:2125-31

Carteau, S; Hoffmann, C; Bushman, F (1998) Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target. J Virol 72:4005-14

Miller, M D; Farnet, C M; Bushman, F D (1997) Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J Virol 71:5382-90

Farnet, C M; Bushman, F D (1997) HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro. Cell 88:483-92

Bushman, F D; Miller, M D (1997) Tethering human immunodeficiency virus type 1 preintegration complexes to target DNA promotes integration at nearby sites. J Virol 71:458-64

Bor, Y C; Miller, M D; Bushman, F D et al. (1996) Target-sequence preferences of HIV-1 integration complexes in vitro. Virology 222:283-8

Farnet, C M; Bushman, F D (1996) HIV cDNA integration: molecular biology and inhibitor development. AIDS 10 Suppl A:S3-11

Miller, M D; Bor, Y C; Bushman, F (1995) Target DNA capture by HIV-1 integration complexes. Curr Biol 5:1047-56