Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI037639-01A2
Application #
2074470
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Newman, Simon L; Gootee, Lisa; Hilty, Jeremy et al. (2006) Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. J Immunol 176:1806-13
Newman, Simon L; Bhugra, Bindu; Holly, Angela et al. (2005) Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infect Immun 73:770-7
Long, Kristin H; Gomez, Francisco J; Morris, Randall E et al. (2003) Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol 170:487-94
Gildea, L A; Morris, R E; Newman, S L (2001) Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. J Immunol 166:1049-56
Newman, S L (2001) Cell-mediated immunity to Histoplasma capsulatum. Semin Respir Infect 16:102-8
Newman, S L; Holly, A (2001) Candida albicans is phagocytosed, killed, and processed for antigen presentation by human dendritic cells. Infect Immun 69:6813-22
Newman, S L; Gootee, L; Gabay, J E et al. (2000) Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infect Immun 68:5668-72
Strasser, J E; Newman, S L; Ciraolo, G M et al. (1999) Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. J Immunol 162:6148-54
Weingart, C L; Broitman-Maduro, G; Dean, G et al. (1999) Fluorescent labels influence phagocytosis of Bordetella pertussis by human neutrophils. Infect Immun 67:4264-7
Newman, S L; Gootee, L; Kidd, C et al. (1997) Activation of human macrophage fungistatic activity against Histoplasma capsulatum upon adherence to type 1 collagen matrices. J Immunol 158:1779-86