Structural Features of Tcr Recognition in Auatoimmunity

Concannon, Patrick

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI039636-02
• Application #: 2076680
• Study Section: Special Emphasis Panel (SRC)
• Project Start: 1995-09-30
• Project End: 2000-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Benaroya Research Institute at Virginia Mason
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98101

Publications

Brawley, James V; Concannon, Patrick (2002) Complementarity-determining region 1 sequence requirements drive limited V alpha usage in response to influenza hemagglutinin 307-319 peptide. J Immunol 168:3894-901

Brawley, J V; Concannon, P (1999) Systematic mutagenesis of TCR complementarity-determining region 3 residues: a single conservative substitution dramatically improves response to both multiple HLA-DR alleles and peptide variants. J Immunol 163:4946-52

Brawley, J V; Concannon, P (1996) Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residues. J Exp Med 183:2043-51