Abstract

This project utilizes the scid hu mouse to explore HIV 1 induced dysfunction and/or destruction of the central human hematolymphoid microenvironment. This project will analyze whether HIV 1 infection suppresses multilineage and/or lineage committed human hematopoiesis in the scid hu Thy/Liv and Bone models, and will assess the mechanism, i.e. direct infection or indirect cytokine mediated suppression of hematopoiesis. The last aim of the project will ask whether similar mechanisms may be operative in symptomatic or asymptomatic HIV 1 infected individuals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040312-04
Application #
2887296
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Sarver, Nava
Project Start
1996-04-01
Project End
2000-07-31
Budget Start
1999-04-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158

  Publications

Ladell, Kristin; Hazenberg, Mette D; Fitch, Mark et al. (2015) Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1?: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. J Immunol 195:4096-105
Lowe, Margaret M; Mold, Jeff E; Kanwar, Bittoo et al. (2014) Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9:e87877
Sacre, Karim; Criswell, Lindsey A; McCune, Joseph M (2012) Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 14:R155
Kiem, Hans-Peter; Jerome, Keith R; Deeks, Steven G et al. (2012) Hematopoietic-stem-cell-based gene therapy for HIV disease. Cell Stem Cell 10:137-47
Mold, Jeff E; Venkatasubrahmanyam, Shivkumar; Burt, Trevor D et al. (2010) Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science 330:1695-9
Contreras, Xavier; Schweneker, Marc; Chen, Ching-Shih et al. (2009) Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem 284:6782-9
Schweneker, Marc; Favre, David; Martin, Jeffrey N et al. (2008) HIV-induced changes in T cell signaling pathways. J Immunol 180:6490-500
Napolitano, Laura A; Schmidt, Diane; Gotway, Michael B et al. (2008) Growth hormone enhances thymic function in HIV-1-infected adults. J Clin Invest 118:1085-98
Roy, Ann-Marie; Schweighardt, Becky; Eckstein, Lauren A et al. (2005) Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells. J Acquir Immune Defic Syndr 40:267-75
Sieling, Peter A; Torrelles, Jordi B; Stenger, Steffen et al. (2005) The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens. J Immunol 174:2637-44

Showing the most recent 10 out of 32 publications