The decay of HIV and turnover of CD4+ lymphocytes have been described recently as being very rapid suggesting that HIV replication is highly productive and that the turnover of CD4+ cells is high. This application is to extend these observations.
Specific Aim 1 is to define the kinetics of decay of HIV or SIV in the compartments containing HIV by using antiviral agents.
The Second Aim i s to define where SIV is cleared and produced in macaques.
The Third Aim i s to characterize the types of lymphocytes before and after antivirals and to determine the mechanism of their regeneration.
The Fourth Aim i s to compare populations of HIV+ people for lymphocyte subpopulations by examining the telomeric length in sequential samples of CD4+ and CD8+ lymphocytes. The Fifth Aim is to examine CD4 and CD8 lymphocytic tissue/turnover using BrdU studies in monkeys with or without SIV infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040387-03
Application #
2672878
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1996-08-15
Project End
2001-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Aaron Diamond AIDS Research Center
Department
Type
DUNS #
786658872
City
New York
State
NY
Country
United States
Zip Code
10016
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