Microbial pathogens must respond to the host environment in order to survive and cause successful infection. The ability to integrate these diverse signals requires a concert of sensory systems that direct the transcriptional machinery to effect specific bacterial gene expression. The project is focused on understanding the genetic control of these mechanisms. This research is broadly applicable to many bacterial pathogens and may be used to develop new methods to combat infectious diseases.
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| Libby, Stephen J; Brehm, Michael A; Greiner, Dale L et al. (2010) Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107:15589-94 |
| Fang, Ferric C; Rimsky, Sylvie (2008) New insights into transcriptional regulation by H-NS. Curr Opin Microbiol 11:113-20 |
