Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI048682-02
Application #
6804506
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Park, Eun-Chung
Project Start
2003-09-30
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$255,500
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Melder, Deborah C; Pike, Gennett M; VanBrocklin, Matthew W et al. (2015) Model of the TVA receptor determinants required for efficient infection by subgroup A avian sarcoma and leukosis viruses. J Virol 89:2136-48
Pike, Gennett M; Madden, Benjamin J; Melder, Deborah C et al. (2011) Simple, automated, high resolution mass spectrometry method to determine the disulfide bond and glycosylation patterns of a complex protein: subgroup A avian sarcoma and leukosis virus envelope glycoprotein. J Biol Chem 286:17954-67
Melder, Deborah C; Yin, Xueqian; Delos, Sue E et al. (2009) A charged second-site mutation in the fusion peptide rescues replication of a mutant avian sarcoma and leukosis virus lacking critical cysteine residues flanking the internal fusion domain. J Virol 83:8575-86
Delos, Sue E; Brecher, Matthew B; Chen, Zaoying et al. (2008) Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency. J Virol 82:3131-4
Munguia, Audelia; Federspiel, Mark J (2008) Efficient subgroup C avian sarcoma and leukosis virus receptor activity requires the IgV domain of the Tvc receptor and proper display on the cell membrane. J Virol 82:11419-28
Reinisova, Marketa; Senigl, Filip; Yin, Xueqian et al. (2008) A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. J Virol 82:2097-105
Elleder, Daniel; Stepanets, Volodymir; Melder, Deborah C et al. (2005) The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. J Virol 79:10408-19
Elleder, Daniel; Melder, Deborah C; Trejbalova, Katerina et al. (2004) Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses. J Virol 78:13489-500