Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051592-02
Application #
6692635
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Koshy, Rajen
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$257,513
Indirect Cost
Name
University of Kentucky
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Yang, Xiao; Haurigot, Virginia; Zhou, Shangzhen et al. (2010) Inhibition of hepatitis C virus replication using adeno-associated virus vector delivery of an exogenous anti-hepatitis C virus microRNA cluster. Hepatology 52:1877-87
Chang, Kyung-Soo; Jiang, Jieyun; Cai, Zhaohui et al. (2007) Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture. J Virol 81:13783-93
Cai, Zhaohui; Cai, Lei; Jiang, Jieyun et al. (2007) Human serum amyloid A protein inhibits hepatitis C virus entry into cells. J Virol 81:6128-33
Li, Yuan; Ye, Li; Peng, Jin-Song et al. (2007) Morphine inhibits intrahepatic interferon- alpha expression and enhances complete hepatitis C virus replication. J Infect Dis 196:719-30
Chang, Kyung-Soo; Cai, Zhaohui; Zhang, Chen et al. (2006) Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities. J Virol 80:7364-74
Cai, Zhaohui; Zhang, Chen; Chang, Kyung-Soo et al. (2005) Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells. J Virol 79:13963-73
Meehl, Michael A; Caparon, Michael G (2004) Specificity of streptolysin O in cytolysin-mediated translocation. Mol Microbiol 52:1665-76
Cai, Zhaohui; Liang, T Jake; Luo, Guangxiang (2004) Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell. J Virol 78:3633-43
Luo, Guangxiang; Xin, Shaojie; Cai, Zhaohui (2003) Role of the 5'-proximal stem-loop structure of the 5' untranslated region in replication and translation of hepatitis C virus RNA. J Virol 77:3312-8