This competing-continuation T32 application (Advanced Training in Oral Biology) requests funding to support the research career development of eligible applicants who wish to pursue careers as independent investigators and leaders in dental, oral, and craniofacial health research. Trainees of our long-established program are encouraged to follow their interests to become prepared to lead a research program involving basic, translational and/or clinical research, participate as expert investigators in multidisciplinary team science projects, and provide leadership in biomedical science research. The major research areas encompassed by the program include microbiology, salivary research, genomics-glycomics-microbiome studies, craniofacial and tooth development, hard-tissue biology, host defense, and periodontal research. The proposed duration of the training leading to completion of the PhD degree is 4 years. For post-doctoral training, 3 years are proposed. The Ph.D. and post-doctoral training programs in the Department of Oral Biology at the University at Buffalo (UB) School of Dental Medicine have to date supported 90 individuals who have earned their Ph.D. degree in Oral Biology, and a large number of post-doctoral fellows, most of whom entered the faculties of numerous dental schools, research institutes, and industry research programs throughout the world. The Training Faculty includes a diverse mix of 23 investigators who lead productive research programs with substantial experience in training pre-doctoral and postdoctoral fellows. Trainees will benefit from many available resources and learning opportunities, including a strong didactic curriculum, journal clubs and seminars, access to basic science and clinical research core facilities, and career development activities. After successfully completing their training, we anticipate our trainees to have reached a level of experience in experimental techniques, scientific thinking, and academic skills that will enable them to pursue successful careers as independent scientists in research, industry, and clinic.

Public Health Relevance

The Advanced Training in Oral Biology program at the School of Dental Medicine at the University at Buffalo offers a wide range of research-intensive interdisciplinary graduate and post-doctoral programs to train the next generation of oral health biomedical scientists. The goal of the program is to attract pre-doctoral and post- doctoral trainees into oral biology research careers. This proposal requests continuation of support for both our Ph.D. program to train dentists (post-D.D.S.) and non-dentists (pre-doctoral), and for our post-doctoral program to train post-doctoral fellows.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE023526-08
Application #
9969387
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2013-07-01
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
038633251
City
Amherst
State
NY
Country
United States
Zip Code
14228
Ruscitto, A; Sharma, A (2018) Peptidoglycan synthesis in Tannerella forsythia: Scavenging is the modus operandi. Mol Oral Microbiol 33:125-132
Min, Sangwon; Song, Eun-Ah Christine; Oyelakin, Akinsola et al. (2018) Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line. PLoS One 13:e0192775
Settem, R P; Honma, K; Shankar, M et al. (2018) Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes. Mol Oral Microbiol 33:292-299
Norris, Hannah L; Friedman, Justin; Chen, Ziqiang et al. (2018) Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels. J Oral Microbiol 10:1447216
Cross, Benjamin W; Ruhl, Stefan (2018) Glycan recognition at the saliva - oral microbiome interface. Cell Immunol 333:19-33
Jones, M M; Vanyo, S T; Visser, M B (2017) The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis. Mol Oral Microbiol 32:375-389
McCall, Andrew; Edgerton, Mira (2017) Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development. J Fungi (Basel) 3:
Honma, Kiyonobu; Ruscitto, Angela; Sharma, Ashu (2017) ?-glucanase activity of the oral bacterium Tannerella forsythia contributes to the growth of a partner species, Fusobacterium nucleatum, in co-biofilms. Appl Environ Microbiol :
Jephthah, Stephanie; Henriques, João; Cragnell, Carolina et al. (2017) Structural Characterization of Histatin 5-Spermidine Conjugates: A Combined Experimental and Theoretical Study. J Chem Inf Model 57:1330-1341
Chinthamani, Sreedevi; Settem, Rajendra P; Honma, Kiyonobu et al. (2017) Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia. PLoS One 12:e0173394

Showing the most recent 10 out of 46 publications