The goal of this application is to obtain support for our long-standing and extremely successful training program in oral health research. We will take advantage of new opportunities to strengthen our tradition of training promising scientists to become leaders as research faculty in the nation's dental, medical, and health-related research institutions. The proposed program will foster interdisciplinary training opportunities in both basc and translational research that address oral health and diseases in order to produce a cadre of well-trained and eventually independent investigators. This application promotes continuing collaboration between several units within UB, including the Schools of Dental Medicine, Medicine and Biomedical Sciences, Engineering and Applied Sciences, and Public Health and Health Professions, the Buffalo Center for Ontological Research, and the Roswell Park Cancer Institute (RPCI). Also, the Center for Excellence in Bioinformatics and Life Sciences (COEBLS) at UB has taken a prominent role in providing interesting and novel research opportunities for our trainees. The organization and requirements of the program center on oral health research, yet take advantage of the numerous other interdisciplinary and cross-training opportunities available. This program will support two training pathways:
Aim 1. Doctoral (PhD) training for dentist and non-dentist trainees Aim 2. Post-Doctoral training for DDS and/or PhD fellows to develop as independent investigators in dental, oral, and craniofacial research The organization and requirements of the program center on oral health research, yet take advantage of numerous interdisciplinary, interprofessional, and cross-training opportunities. Implementing these aims will benefit trainees, investigators, and research staff across a broad range of disciplines and levels of training.

Public Health Relevance

The Oral Biology graduate program at the School of Dental Medicine at the University at Buffalo offers a wide range of research-intensive interdisciplinary graduate and post-doctoral programs aimed at creating the next generation of dental and craniofacial health professionals. The purpose of this project is to attract new pre-doctoral and post-doctoral trainees into dental research careers - especially those talented students who may not have considered oral health research as a career path. This proposal requests institutional support for both our PhD program to train dentists (post-doctoral) and non-dentists (pre-doctoral), and for our post-doctoral program to train non-clinician PhD fellows.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDE1-RK (07))
Program Officer
King, Lynn M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University of New York at Buffalo
Schools of Dentistry
United States
Zip Code
Ruscitto, A; Sharma, A (2018) Peptidoglycan synthesis in Tannerella forsythia: Scavenging is the modus operandi. Mol Oral Microbiol 33:125-132
Min, Sangwon; Song, Eun-Ah Christine; Oyelakin, Akinsola et al. (2018) Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line. PLoS One 13:e0192775
Settem, R P; Honma, K; Shankar, M et al. (2018) Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes. Mol Oral Microbiol 33:292-299
Norris, Hannah L; Friedman, Justin; Chen, Ziqiang et al. (2018) Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels. J Oral Microbiol 10:1447216
Cross, Benjamin W; Ruhl, Stefan (2018) Glycan recognition at the saliva - oral microbiome interface. Cell Immunol 333:19-33
Kiripolsky, Jeremy; McCabe, Liam G; Gaile, Daniel P et al. (2017) Myd88 is required for disease development in a primary Sjögren's syndrome mouse model. J Leukoc Biol 102:1411-1420
Du, Han; Puri, Sumant; McCall, Andrew et al. (2017) Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens. Front Cell Infect Microbiol 7:41
Leigh, Noel J; Nelson, Joel W; Mellas, Rachel E et al. (2017) Three-dimensional cultures of mouse submandibular and parotid glands: a comparative study. J Tissue Eng Regen Med 11:618-626
Ruscitto, Angela; Honma, Kiyonobu; Veeramachineni, Vamsee M et al. (2017) Regulation and Molecular Basis of Environmental Muropeptide Uptake and Utilization in Fastidious Oral Anaerobe Tannerella forsythia. Front Microbiol 8:648
Jones, M M; Vanyo, S T; Visser, M B (2017) The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis. Mol Oral Microbiol 32:375-389

Showing the most recent 10 out of 46 publications