Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051949-02
Application #
6766002
Study Section
AIDS and Related Research 8 (AARR)
Program Officer
Duncan, Rory A
Project Start
2003-07-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$309,486
Indirect Cost
Name
Georgetown University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Andaluz, E; Bellido, A; Gomez-Raja, J et al. (2011) Rad52 function prevents chromosome loss and truncation in Candida albicans. Mol Microbiol 79:1462-82
Garcia-Prieto, Fatima; Gomez-Raja, Jonathan; Andaluz, Encarnacion et al. (2010) Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agents. Fungal Genet Biol 47:433-45
Gomez-Raja, Jonathan; Andaluz, Encarnacion; Magee, Beatrice et al. (2008) A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strains. Fungal Genet Biol 45:527-41
Andaluz, Encarnacion; Gomez-Raja, Jonathan; Hermosa, Belen et al. (2007) Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-DeltaDelta strains of Candida albicans to sorbose. Fungal Genet Biol 44:789-98
Andaluz, Encarnacion; Ciudad, Toni; Gomez-Raja, Jonathan et al. (2006) Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes. Mol Microbiol 59:1452-72
Chauhan, Neeraj; Ciudad, Toni; Rodriguez-Alejandre, Ane et al. (2005) Virulence and karyotype analyses of rad52 mutants of Candida albicans: regeneration of a truncated chromosome of a reintegrant strain (rad52/RAD52) in the host. Infect Immun 73:8069-78
Ciudad, Toni; Andaluz, Encarnacion; Steinberg-Neifach, Olga et al. (2004) Homologous recombination in Candida albicans: role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length. Mol Microbiol 53:1177-94