Immunoglobulin Somatic Mutation

Storb, Ursula B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI053130-02
• Application #: 6685879
• Study Section: Allergy and Immunology Study Section (ALY)
• Program Officer: Nasseri, M Faraz
• Project Start: 2002-12-01
• Project End: 2007-11-30
• Budget Start: 2003-12-01
• Budget End: 2004-11-30
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $261,835

Institution

• Name: University of Chicago
• Department: Genetics
• Type: Schools of Medicine
• DUNS #: 005421136
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60637

Publications

Kodgire, Prashant; Mukkawar, Priyanka; North, Justin A et al. (2012) Nucleosome stability dramatically impacts the targeting of somatic hypermutation. Mol Cell Biol 32:2030-40

Tanaka, Atsushi; Shen, Hong Ming; Ratnam, Sarayu et al. (2010) Attracting AID to targets of somatic hypermutation. J Exp Med 207:405-15

Ratnam, Sarayu; Bozek, Grazyna; Nicolae, Dan et al. (2010) The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol 47:2611-8

Storb, Ursula; Shen, Hong Ming; Nicolae, Dan (2009) Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils. Cell Cycle 8:3097-101

Shen, Hong Ming; Bozek, Grazyna; Pinkert, Carl A et al. (2008) Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol 45:1883-92

Longerich, Simonne; Orelli, Brian J; Martin, Richard W et al. (2008) Brca1 in immunoglobulin gene conversion and somatic hypermutation. DNA Repair (Amst) 7:253-66

Longerich, Simonne; Meira, Lisiane; Shah, Dharini et al. (2007) Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination. DNA Repair (Amst) 6:1764-73

Storb, Ursula; Shen, Hong Ming; Longerich, Simonne et al. (2007) Targeting of AID to immunoglobulin genes. Adv Exp Med Biol 596:83-91

Shen, Hong Ming (2007) Activation-induced cytidine deaminase acts on double-strand breaks in vitro. Mol Immunol 44:974-83

Shen, Hong Ming; Tanaka, Atsushi; Bozek, Grazyna et al. (2006) Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J Immunol 177:5386-92