Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI054178-02
Application #
6691660
Study Section
AIDS and Related Research 8 (AARR)
Program Officer
Plaeger, Susan F
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$432,500
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Brockman, Mark A; Brumme, Zabrina L; Brumme, Chanson J et al. (2010) Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. J Virol 84:11937-49
Wang, Yaoyu E; Li, Bin; Carlson, Jonathan M et al. (2009) Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J Virol 83:1845-55
Streeck, Hendrik; Jessen, Heiko; Kuecherer, Claudia et al. (2009) Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS 23:259-62
Schneidewind, Arne; Tang, Yanhua; Brockman, Mark A et al. (2009) Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant. J Virol 83:8616-27
Dalmau, Judith; Puertas, Maria Carmen; Azuara, Marta et al. (2009) Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection. Clin Infect Dis 48:229-38
Schneidewind, Arne; Brumme, Zabrina L; Brumme, Chanson J et al. (2009) Transmission and long-term stability of compensated CD8 escape mutations. J Virol 83:3993-7
Schneidewind, Arne; Brockman, Mark A; Sidney, John et al. (2008) Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol 82:5594-605
Streeck, Hendrik; Li, Bin; Poon, Art F Y et al. (2008) Immune-driven recombination and loss of control after HIV superinfection. J Exp Med 205:1789-96
Li, Bin; Gladden, Adrianne D; Altfeld, Marcus et al. (2007) Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution. J Virol 81:193-201
Schneidewind, Arne; Brockman, Mark A; Yang, Ruifeng et al. (2007) Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J Virol 81:12382-93

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